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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Oncologic Safety in Solid Organ Transplant Recipients With a Past Medical History of Early-stage Melanoma: A Retrospective Cohort Study.

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Multicenter Observational Study on Recurrence Patterns and Health Care Resource Utilization in Stage II Cutaneous Melanoma in Spain: Real-world Evidence From the METHEOR Study.

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Complete Lymph Node Dissection vs Observation in Patients With Cutaneous Melanoma and Positive Sentinel Lymph Node Biopsy With High-risk Criteria: Multicenter Analysis in Hospitals in the Mediterranean Area.

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Acral Melanoma in the Caucasian Population: A Comprehensive Cohort Study on Epidemiological, Clinicopathological, and Prognostic Features.

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Acral Melanoma in the Caucasian Population: A Comprehensive Cohort Study on Epidemiological, Clinicopathological, and Prognostic Features.

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[Translated article] Multicenter Analysis of the Surgical Management and Adjuvant Therapy of Patients With Melanoma and a Positive Sentinel Lymph Node Biopsy.

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A Melanoma Patient-Derived Xenograft Model
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RF - Neoadjuvant Therapy in Melanoma

A Arrieta1, M Blanco de Tord1, A Boada2

  • 1Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Barcelona, España; Institut d'Investigació Germans Trias i Pujol, Badalona, Barcelona, España.

Actas Dermo-Sifiliograficas
|September 8, 2022
PubMed
Summary

No abstract available in PubMed .

Keywords:
Cirugía conservadoraConservative surgeryGanglio índiceIndex lymph nodeMelanomaNeoadjuvant therapyNeoadyuvanciaPathologic responseRespuesta patológica

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