Related Experiment Video

Updated: Aug 29, 2025

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.5K

Growth patterns among late preterm infants of mothers with diabetes

Catherine O Buck1, Veronika Shabanova1, Sarah N Taylor1

  • 1Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|September 8, 2022
PubMed

Insights

Infants born prematurely to mothers with diabetes had higher birth weights and experienced accelerated weight gain in the first week of life. These growth differences persisted to age two, indicating a need for further research into long-term risks.

Area of Science:

  • Neonatal and Developmental Pediatrics
  • Maternal-Fetal Medicine
  • Pediatric Endocrinology

Background:

  • Maternal diabetes mellitus (DM) is a known risk factor for offspring obesity and cardiometabolic diseases.
  • Limited data exist on the growth patterns of preterm infants exposed to maternal diabetes during gestation.

Purpose of the Study:

  • To compare early childhood growth trajectories between late preterm infants born to mothers with and without diabetes during pregnancy.

Main Methods:

  • A retrospective longitudinal analysis compared weight trajectories from birth to 2 years.
  • Mixed-effects modeling was used, adjusting for maternal and infant demographic covariates.
  • The study included 1554 late preterm infants, with 134 exposed to maternal diabetes.

Main Results:

  • Infants exposed to maternal diabetes (DM-group) had higher average birth weight (300g difference) and weight z-scores (0.67 SDS difference).
  • DM-group infants exhibited accelerated weight gain from birth to discharge and in the first postnatal week.
  • Higher average weight and weight z-scores were maintained through age two, with increased weight gain between 18 and 24 months.

Conclusions:

  • Late preterm infants exposed to maternal diabetes demonstrate increased weight from birth to age two and accelerated early postnatal growth.
  • Further investigation is warranted to understand the long-term health implications of these altered weight trajectories.
Abstract

Keywords:
Late preterm infantsdiabetes in pregnancygrowthgrowth trajectoriesprematurity

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.4K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

732

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.7K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
664
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.0K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.5K