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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Related Experiment Video

Updated: Aug 29, 2025

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
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Non-alcoholic steatohepatitis.

Manuel Romero-Gómez1

  • 1Servicio de Aparato Digestivo, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHD), Departamento de Medicina, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (HUVR/CSIC/US), Universidad de Sevilla, Sevilla, España.

Medicina Clinica
|September 8, 2022
PubMed
Summary

Non-alcoholic steatohepatitis (NASH) is a complex liver disease linked to metabolic issues. Lifestyle changes and targeted therapies can help manage steatosis, inflammation, and fibrosis.

Keywords:
Cardiovascular diseaseCirrhosisCirrosis hepáticaEnfermedad cardio-vascularEsteatohepatitisEsteatosisExtrahepatic neoplasmsFibrosisFibrosis hepáticaNeoplasias extrahepáticasSteatohepatitisSteatosis

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Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells
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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
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Area of Science:

  • Hepatology
  • Metabolic Disorders
  • Internal Medicine

Background:

  • Non-alcoholic steatohepatitis (NASH) is part of metabolic-associated fatty liver disease (MAFLD), associated with obesity, diabetes, metabolic syndrome, and dyslipidemia.
  • MAFLD is characterized by high prevalence, heterogeneity, complexity, and a dynamic disease course.
  • Key clinical symptoms like pruritus and asthenia significantly impact patient quality of life and reported outcomes.

Purpose of the Study:

  • To outline the diagnostic approaches for NASH, including non-invasive biochemical and imaging tests.
  • To highlight the role of liver biopsy as the gold standard for NASH diagnosis.
  • To review current and emerging therapeutic strategies for managing NASH.

Main Methods:

  • Lifestyle interventions such as Mediterranean hypocaloric diets for weight loss and exercise to combat sarcopenia.
  • Alcohol abstinence is recommended.
  • Pharmacological therapies targeting obesity, diabetes, and fibrosis are employed for non-responders, used sequentially or in combination.

Main Results:

  • Lifestyle modifications are the cornerstone of NASH management.
  • Non-invasive tests aid in diagnosis, but liver biopsy remains definitive.
  • Pharmacological treatments aim to regress steatosis, inflammation, and fibrosis.

Conclusions:

  • NASH requires a multifaceted approach involving lifestyle changes and medical therapies.
  • Effective management can lead to regression of liver disease components.
  • Further research into novel drug therapies is crucial for improving patient outcomes.