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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Related Experiment Video

Updated: Aug 29, 2025

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
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Should we stop screening for chronic endometritis?

Ezgi Darici1, Christophe Blockeel1, Shari Mackens1

  • 1Brussels IVF, Centre for Reproductive Medicine Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Reproductive Biomedicine Online
|September 8, 2022
PubMed
Summary

Chronic endometritis, an inflammatory uterine condition, impacts embryo implantation. This review critically appraises its diagnosis and treatment for improved IVF outcomes.

Keywords:
Chronic endometritisDiagnosisRecurrent implantation failureRecurrent pregnancy lossTreatment

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Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Embryology

Background:

  • Chronic endometritis is an underdiagnosed uterine condition potentially affecting embryo implantation.
  • Its prevalence varies widely (2-60%), with higher suspicion in cases of recurrent pregnancy loss and implantation failure.
  • The impact of chronic endometritis on IVF outcomes requires further clarification due to limited data.

Purpose of the Study:

  • To critically evaluate current diagnostic methods for chronic endometritis.
  • To review existing treatment strategies for chronic endometritis.
  • To identify patient populations that would benefit from chronic endometritis screening.

Main Methods:

  • Literature review of diagnostic techniques (e.g., hysteroscopy, biopsy, molecular methods).
  • Analysis of treatment efficacy studies (e.g., antibiotic therapy).
  • Assessment of evidence linking chronic endometritis to IVF success rates.

Main Results:

  • Diagnostic accuracy and clinical utility of various methods are debated.
  • Evidence supporting improved IVF outcomes after chronic endometritis treatment is inconclusive.
  • Specific patient subgroups may benefit from targeted screening and treatment.

Conclusions:

  • Accurate diagnosis and effective treatment of chronic endometritis remain challenging.
  • Further research is needed to establish clear diagnostic criteria and treatment guidelines.
  • Optimizing management of chronic endometritis may enhance reproductive success in select infertile populations.