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Apoptosis evasion via long non-coding RNAs in colorectal cancer

Muhammad Irfan1, Zeeshan Javed2, Khushbukhat Khan1

  • 1Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.

Cancer Cell International
|September 8, 2022
PubMed

Insights

Long non-coding RNAs (LncRNAs) are key regulators of gene expression and cellular activities in colorectal cancer (CRC). This review explores how lncRNAs influence apoptosis and their potential as diagnostic and prognostic biomarkers in CRC.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (LncRNAs) are regulatory transcripts implicated in various cancers, including colorectal cancer (CRC).
  • Aberrant expression of lncRNAs is common in CRC cells, affecting cellular processes.
  • LncRNAs play a role in cancer progression, chemoresistance, and apoptosis.

Purpose of the Study:

  • To review the functions and mechanisms of lncRNAs in regulating gene expression related to apoptosis in CRC.
  • To discuss how colorectal cancer cells evade apoptosis.
  • To highlight the potential of lncRNAs as biomarkers for CRC diagnosis and prognosis.

Main Methods:

  • Literature review focusing on lncRNA function in colorectal cancer.
  • Analysis of molecular mechanisms underlying lncRNA-mediated gene regulation.
  • Examination of apoptotic pathways in normal and cancer cells.

Main Results:

  • LncRNAs are dysregulated in CRC, influencing cell proliferation, invasion, metastasis, chemoresistance, and apoptosis.
  • Both oncogenic and tumor suppressor lncRNAs impact apoptotic pathways in CRC.
  • LncRNAs can promote or inhibit apoptosis in colorectal cancer cells.

Conclusions:

  • LncRNAs are critical regulators of apoptosis in colorectal cancer.
  • Understanding lncRNA mechanisms in CRC apoptosis is crucial for therapeutic strategies.
  • LncRNAs show promise as biomarkers for colorectal cancer prognosis and diagnosis.
Keywords:
ApoptosisColorectal cancerEpigeneticLong Non-coding RNAmiRNA

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