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Updated: Aug 29, 2025

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
Published on: February 4, 2016
Why study mechanisms of brain stimulation therapies? To modulate the right neurons, in the right way, at the right
Matthew J McGinley1, Steven T Lee2
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA; Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Abstract:
Clinical applications of vagus nerve stimulation (VNS) are burgeoning, but mechanistic work lags behind. In this issue of Neuron, Bowles and colleagues show that VNS timed with positive reinforcement improves motor learning and cortical function by a cholinergic mechanism.
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