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Which are the optimal thromboprophylaxis strategies for hospitalized patients with COVID-19? current controversies

Mateo Porres-Aguilar1, Debabrata Mukherjee2, S Claudia Didia1

  • 1Department of Internal Medicine, Divisions of Hospital and Adult Clinical Thrombosis Medicine, Texas Tech University Health Sciences Center and Paul L. Foster School of Medicine, El Paso, TX, USA.

Vascular
|September 9, 2022
PubMed

Insights

COVID-19 increases the risk of venous thromboembolism (VTE) in hospitalized patients. This review examines thromboprophylaxis strategies and discusses anticoagulation controversies, especially for moderate COVID-19 cases.

Area of Science:

  • Internal Medicine
  • Cardiology
  • Pulmonology

Background:

  • COVID-19 is a significant risk factor for venous thromboembolism (VTE).
  • Hospitalized patients with moderate to severe/critical COVID-19 face elevated VTE risks.
  • Understanding optimal VTE prevention is crucial for patient outcomes.

Purpose of the Study:

  • To review current thromboprophylaxis strategies for COVID-19 patients.
  • To discuss controversies surrounding anticoagulation in VTE prevention.
  • To offer a perspective on managing VTE risk in moderately ill COVID-19 patients.

Main Methods:

  • Literature review of emerging data on thromboprophylaxis.
  • Analysis of current anticoagulation guidelines and practices.
  • Discussion of clinical controversies and expert opinion.

Main Results:

  • COVID-19 is strongly associated with increased VTE risk.
  • Various thromboprophylaxis strategies are under investigation.
  • Debate exists regarding the optimal intensity and duration of anticoagulation, particularly in moderate cases.

Conclusions:

  • Effective VTE prophylaxis is essential for hospitalized COVID-19 patients.
  • Further research is needed to clarify optimal anticoagulation strategies.
  • Personalized approaches may be necessary for managing VTE risk in different COVID-19 severity groups.

Keywords:
COVID-19heparinsoutcomestherapeutic anticoagulationthromboprophylaxisvenous thromboembolism

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