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ELIME Enzyme Linked Immuno Magnetic Electrochemical Method for Mycotoxin Detection
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Opinion: Multi-Mycotoxin Reference Materials.

Kai Zhang1, Melissa Phillips2

  • 1Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5001 Campus Drive, College Park, MD 20747, USA.

Foods (Basel, Switzerland)
|September 9, 2022
PubMed
Summary
This summary is machine-generated.

Certified reference materials are crucial for accurate multi-mycotoxin analysis using liquid chromatography-mass spectrometry. Extending their use improves data quality and consistency in food and feed testing.

Keywords:
FDANISTmulti-mycotoxin reference materials

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Area of Science:

  • Analytical Chemistry
  • Food Safety
  • Mass Spectrometry

Background:

  • Liquid chromatography coupled with mass spectrometry (LC-MS) allows simultaneous detection of multiple mycotoxins in food and feed.
  • Accurate multi-mycotoxin analysis necessitates stringent quality control (QC) parameters for reliable data.
  • Mycotoxin matrix reference materials (RMs), particularly certified RMs (CRMs), offer traceability and characterized concentrations.

Purpose of the Study:

  • To discuss the essential components for improving data quality in multi-mycotoxin analysis.
  • To highlight the importance and application of reference materials in multi-mycotoxin determination.
  • To advocate for the extended use of RMs in routine multi-mycotoxin analysis.

Main Methods:

  • Discussion of metrological and operational aspects of multi-mycotoxin reference materials.
  • Comparison of different types of quality control materials: RMs, CRMs, and in-house controls.
  • Review of current trends and challenges associated with multi-mycotoxin RMs.

Main Results:

  • Reference materials, especially CRMs, provide essential traceability, concentration, and uncertainty data for mycotoxins.
  • The established practice of using RMs for single mycotoxin analysis should be expanded to multi-mycotoxin methods.
  • Incorporating RMs into QC processes enhances the development and implementation of LC-MS multi-mycotoxin methods.

Conclusions:

  • Utilizing reference materials in multi-mycotoxin analysis significantly improves data accuracy and consistency.
  • Standardized use of RMs is key to ensuring reliable results in routine mycotoxin testing.
  • Adoption of RMs supports the successful development and validation of advanced LC-MS based multi-mycotoxin methods.