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Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review.

Wenwen Lv1,2,3,4,5,6, Duoxia Xu1,2,3,4,5,6

  • 1Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China.

Foods (Basel, Switzerland)
|September 9, 2022
PubMed
Summary

Docosahexaenoic acid (DHA) delivery systems improve its bioavailability and stability for enhanced health benefits. These systems overcome limitations, maximizing DHA

Keywords:
DHA delivery systemsanti-obesitybioavailabilitydigestionfood applications

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Area of Science:

  • Nutritional Science and Food Technology
  • Biomedical Engineering

Background:

  • Docosahexaenoic acid (DHA), sourced from microalgae and fish oil, is vital for visual, neurological, and brain development.
  • DHA exhibits anti-inflammatory, anti-obesity, and anti-adipogenesis effects, potentially improving metabolic disorders.
  • Challenges in food applications include DHA's low water solubility, instability, and poor bioavailability.

Purpose of the Study:

  • To review various DHA delivery systems and their in vitro/in vivo digestive characteristics.
  • To explore research progress on DHA delivery systems for cardiovascular diseases, diabetes, visual/neurological health, and anti-obesity applications.
  • To discuss future trends and development potential of DHA delivery systems in food applications.

Main Methods:

  • Comprehensive literature review of DHA delivery systems.
  • Analysis of in vitro and in vivo digestive studies.
  • Synthesis of research on health applications and food technology advancements.

Main Results:

  • DHA delivery systems effectively enhance DHA stability during gastrointestinal digestion.
  • These systems significantly improve DHA bioavailability and functional efficacy.
  • Reviewed systems show promise for various health conditions and food product development.

Conclusions:

  • DHA delivery systems are crucial for overcoming inherent limitations of DHA.
  • They enhance DHA's therapeutic and nutritional potential across diverse applications.
  • Further development holds significant promise for improving public health and food innovation.