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Polygenic Risk of Hypertriglyceridemia Is Modified by BMI
Virginia Esteve-Luque1,2,3, Marta Fanlo-Maresma1,2,3, Ariadna Padró-Miquel2,4
1Cardiovascular Risk Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
International Journal of Molecular Sciences
|September 9, 2022
Summary
Genetic risk scores (GRSs) are linked to triglyceride levels. Body mass index (BMI) significantly amplifies this genetic effect, aiding in identifying individuals needing intensive hypertriglyceridemia care.
Area of Science:
- Genetics
- Metabolic Disorders
- Cardiovascular Health
Background:
- Genetic risk scores (GRSs) offer insights into hypertriglyceridemia (HTG) etiology.
- HTG was previously primarily attributed to secondary causes.
Purpose of the Study:
- To investigate the interaction between clinical variables and GRS in HTG.
- To understand variability in HTG based on genetic and clinical factors.
Main Methods:
- Analyzed 276 patients with suspected polygenic HTG.
- Developed an unweighted GRS using specific gene variants.
- Evaluated interactions between GRS and clinical variables like BMI, diabetes, diet, and lifestyle.
Main Results:
- The GRS showed a significant association with triglyceride (TG) concentrations.
- A significant interaction between BMI and GRS was observed.
- Higher BMI intensified the relationship between genetic alleles and TG levels.
Conclusions:
- GRS is associated with plasma TG concentrations and is significantly influenced by BMI.
- This interaction can improve patient stratification for HTG.
- Identifies individuals at high genetic risk for HTG who may benefit from targeted interventions.
Keywords:
dyslipidemiagenetic risk scoregene–environment interactionhypercholesterolemiaobesitypolygenic hypertriglyceridemiaMore Related Videos
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