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Engineering Bio-Adhesives Based on Protein-Polysaccharide Phase Separation.

Zoobia Bashir1, Wenting Yu2, Zhengyu Xu1

  • 1Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University, Nanjing 210093, China.

International Journal of Molecular Sciences
|September 9, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a novel bio-adhesive for tissue repair and bioelectronic devices. The new adhesive offers strong, rapid, and long-lasting adhesion, even in wet conditions, improving upon existing glues.

Keywords:
bio-adhesivesdopaphase separationtissue adhesionwet adhesion

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Adhesive Technology

Background:

  • Glue-type bio-adhesives are crucial for medical applications like wound closure and bioelectronic device integration.
  • Current bio-adhesives often lack sufficient instant cohesion for short-term tissue adhesion.
  • There is a need for advanced bio-adhesives with enhanced adhesion properties and in situ applicability.

Purpose of the Study:

  • To develop a novel glue-type bio-adhesive with improved instant and long-term adhesion.
  • To investigate the phase separation behavior of functionalized polysaccharides for enhanced adhesion.
  • To evaluate the bio-adhesive's performance in aqueous environments and on various substrates, including wet tissues.

Main Methods:

  • Functionalization of polysaccharides with dopa to induce phase separation.
  • Formulation of a novel bio-adhesive based on protein and functionalized polysaccharide interactions.
  • Characterization of adhesion strength (shear strength) and interfacial toughness.
  • In vitro testing on various visceral tissues to assess biocompatibility and adhesion efficacy.

Main Results:

  • The novel bio-adhesive demonstrated significantly enhanced adhesion performance and phase separation.
  • Achieved long-term adhesion strength of 1.48 MPa (shear strength) on wet tissues.
  • Exhibited high interfacial toughness of approximately 880 J m-2.
  • Maintained normal function in aqueous environments due to unique phase separation behaviors.
  • Showcased excellent biocompatibility and feasibility for visceral tissue adhesion in vitro.

Conclusions:

  • The developed bio-adhesive offers robust instant and long-term adhesion for diverse substrates, including wet tissues.
  • Its ability to function in aqueous environments and excellent biocompatibility make it suitable for biomedical applications.
  • This novel bio-glue holds significant potential for widespread use in clinical settings for tissue adhesion and repair.