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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma.

Gerhard Garhöfer1, Ahmed M Bata1,2, Alina Popa-Cherecheanu3,4

  • 1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.

International Journal of Molecular Sciences
|September 9, 2022
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Summary

Primary open-angle glaucoma (POAG) is linked to reduced retinal oxygen extraction. This non-invasive finding may help track disease progression.

Keywords:
Doppler optical coherence tomographyglaucomaretinal blood flowretinal oxygen extraction

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Area of Science:

  • Ophthalmology
  • Medical Research
  • Cardiovascular Science

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Understanding the pathophysiology of POAG is crucial for developing effective treatments.
  • Retinal oxygen metabolism plays a vital role in ocular health.

Purpose of the Study:

  • To compare total retinal oxygen extraction between POAG patients and healthy controls.
  • To investigate the relationship between retinal oxygen extraction and disease severity in POAG.

Main Methods:

  • A prospective, cross-sectional study involving 40 POAG patients and 40 controls.
  • Retinal blood flow measured using Doppler optical coherence tomography (OCT).
  • Retinal oxygen saturation assessed via reflectance spectroscopy to calculate extraction.

Main Results:

  • POAG patients exhibited significantly lower total retinal blood flow compared to controls.
  • Retinal venous oxygen content was higher in POAG, indicating reduced oxygen extraction.
  • Reduced retinal oxygen extraction was significantly associated with structural and functional damage in POAG.

Conclusions:

  • POAG is associated with diminished total retinal oxygen extraction.
  • This reduction is linked to the structural and functional damage characteristic of POAG.
  • Non-invasive measurement allows for future longitudinal studies on POAG progression.