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Related Experiment Video

Updated: Aug 29, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence.

Eman A Toraih1,2, Manal S Fawzy3,4, Bo Ning5

  • 1Division of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.

Cancers
|September 9, 2022
PubMed

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Cancer investigation·2026
Summary

MicroRNA-145 (miR-145) is significantly reduced in papillary thyroid carcinoma (PTC) tissues and blood. This downregulation correlates with tumor progression and may serve as a biomarker for PTC recurrence.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Papillary thyroid carcinoma (PTC) is the most common endocrine tumor.
  • Screening and diagnosing PTC recurrence presents clinical challenges.

Purpose of the Study:

  • To identify microRNAs (miRNAs) associated with PTC recurrence and metastasis.
  • To investigate the role of miR-145 in PTC.

Main Methods:

  • MicroRNA sequencing (miR-seq) on PTC tissues and adjacent normal tissues.
  • Data validation using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.
  • Quantitative real-time PCR (qRT-PCR) for miR-145 expression analysis.
  • In silico analysis of miR-145 targets in the TC signaling pathway.
Keywords:
microRNAprogressionrecurrencethyroid cancer

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Last Updated: Aug 29, 2025

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Main Results:

  • miR-145 was significantly downregulated in PTC tumor tissues and patient blood.
  • Reduced miR-145 levels correlated with tumor size, lymph node metastasis, TNM stage, and recurrence.
  • In silico analysis indicated miR-145 negatively regulates TC signaling pathway genes involved in apoptosis, proliferation, angiogenesis, and metastasis.

Conclusions:

  • miR-145 may serve as a potential biomarker for predicting PTC recurrence.
  • Further research is needed to elucidate the specific cellular functions of miR-145 in PTC progression.