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Demographics, Outcomes, and Risk Factors for Patients with Sarcoma and COVID-19: A CCC19-Registry Based Retrospective
Michael J Wagner1, Cassandra Hennessy2, Alicia Beeghly3
1Department of Medicine, University of Washington, and Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Cancers
|September 9, 2022
Summary
Patients with sarcoma face severe COVID-19 risks, especially those with bone sarcoma. This study analyzed 281 sarcoma patients, revealing high hospitalization and mortality rates, with bone sarcoma patients showing the greatest risk of death.
Area of Science:
- Oncology
- Infectious Diseases
- Epidemiology
Background:
- Sarcoma patients often undergo aggressive immunosuppressive therapies, increasing their vulnerability to severe COVID-19.
- Understanding the specific risks and outcomes for this population is crucial for clinical management.
Purpose of the Study:
- To describe the demographics, risk factors, and outcomes of patients diagnosed with both sarcoma and COVID-19.
- To identify specific sarcoma subtypes or patient characteristics associated with increased COVID-19 severity.
Main Methods:
- Retrospective cohort study utilizing data from the COVID-19 and Cancer Consortium (CCC19) registry.
- Analysis of 281 patients with sarcoma and COVID-19 diagnosed between March 2020 and September 2021.
- Evaluation of demographics, sarcoma type, treatments, and COVID-19 related outcomes, including hospitalization, ICU admission, ventilation, and mortality.
Main Results:
- Nearly half of sarcoma patients (49%) were hospitalized, and 16% died overall.
- Patients with bone sarcoma exhibited a significantly higher mortality rate (13.5%) compared to a matched general population cohort (4.4%).
- Factors associated with severe COVID-19 included older age, poor performance status, recent anti-cancer therapy, and lung metastases.
Conclusions:
- Patients with sarcoma experience high rates of severe COVID-19.
- Bone sarcoma patients represent a particularly high-risk group for COVID-19 mortality.
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