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Related Experiment Video

Updated: Aug 29, 2025

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
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Lung Organoids as Model to Study SARS-CoV-2 Infection.

Li Peng1, Li Gao1, Xinya Wu1

  • 1The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.

Cells
|September 9, 2022
PubMed
Summary
This summary is machine-generated.

Human lung organoids are valuable tools for studying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mechanisms, pathogenesis, and developing treatments for coronavirus disease-2019 (COVID-19). This research offers hope for alleviating COVID-19-related lung damage.

Keywords:
COVID-19SARS-CoV-2coronaviruslungorganoid

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Area of Science:

  • Virology
  • Organoid Technology
  • Infectious Diseases

Background:

  • Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic impacting socio-economic conditions.
  • The lungs are the primary organ targeted and damaged by SARS-CoV-2.
  • Understanding viral mechanisms is crucial for combating COVID-19.

Purpose of the Study:

  • To summarize existing lung organoid models for virological research.
  • To outline human-infecting coronaviruses.
  • To review studies on SARS-CoV-2 using lung organoids for pathogenesis, drug development, and precision treatment.

Main Methods:

  • Literature review of lung organoids and their applications.
  • Compilation of information on human coronaviruses.
  • Synthesis of existing research on SARS-CoV-2 utilizing lung organoids.

Main Results:

  • Human organoids serve as effective platforms for virological research and studying host-pathogen interactions.
  • Lung organoids are instrumental in understanding SARS-CoV-2 pathogenesis.
  • Organoids aid in the development of drugs and precision treatments for COVID-19.

Conclusions:

  • Lung organoids are vital for advancing research into SARS-CoV-2 infection.
  • This research highlights the potential of organoids to alleviate COVID-19-associated lung infections.
  • Organoid technology offers a promising avenue for future COVID-19 research and therapeutic strategies.