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Updated: Aug 29, 2025

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
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Growth Factor Release within Liquid and Solid PRF.

Katharina Zwittnig1, Barbara Kirnbauer1, Norbert Jakse1

  • 1Division of Oral Surgery and Orthodontics, Department of Dental and Oral Health, Medical University of Graz, Billrothgasse 4, 8010 Graz, Austria.

Journal of Clinical Medicine
|September 9, 2022
PubMed
Summary

This study analyzed growth factor release from liquid and solid platelet-rich fibrin (PRF) matrices. Results showed minimal differences between PRF forms, indicating potential for consistent therapeutic applications.

Keywords:
EGFMMP-9PDGF-BBTGFVEGFgrowth factorsoral surgeryplatelet-rich fibrin

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Platelet-rich fibrin (PRF) is utilized in regenerative medicine for its growth factor content.
  • Understanding growth factor release kinetics from PRF is crucial for optimizing therapeutic outcomes.
  • Variations in PRF matrix form (liquid vs. solid) may influence growth factor delivery.

Purpose of the Study:

  • To quantify growth factor release from liquid and solid PRF matrices.
  • To assess interindividual variability in growth factor release.
  • To compare growth factor release profiles between liquid and solid PRF.

Main Methods:

  • Blood samples from four subjects were processed into liquid and solid PRF.
  • Five key growth factors (VEGF, EGF, PDGF-BB, TGF-β1, MMP-9) were measured using ELISA.
  • Measurements were taken at six time points over 10 days.

Main Results:

  • Growth factors were detectable in all PRF samples across all time points.
  • No significant differences in overall growth factor release were observed between liquid and solid PRF (p > 0.05).
  • Specific growth factors exhibited distinct release patterns, with peaks generally occurring around day 7, except for EGF which peaked earlier.

Conclusions:

  • Liquid and solid PRF matrices demonstrate comparable growth factor release profiles with low interindividual variation.
  • Further research with larger sample sizes is warranted to elucidate precise growth factor release dynamics.
  • These findings support the potential of PRF in preclinical and clinical applications for wound healing.