Related Experiment Video

Updated: Aug 29, 2025

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.3K

A Novel Propofol Dosing Regimen for Pediatric Sedation during Radiologic Tests

Ji-Young Min1, Jeong-Rim Lee2, Hye-Mi Lee3

  • 1Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Korea.

Journal of Clinical Medicine
|September 9, 2022
PubMed

Insights

A new propofol dosing equation for pediatric sedation during radiologic tests resulted in quicker sedation and fewer rescue doses compared to conventional methods. However, careful application of the equation is advised.

Area of Science:

  • Pediatric Anesthesiology
  • Radiology
  • Pharmacology

Background:

  • Sedation is crucial for pediatric radiologic imaging.
  • Current propofol dosing strategies may lack precision.
  • A previous study proposed a predictive equation for propofol dosage.

Purpose of the Study:

  • To compare a novel propofol dosing equation with conventional methods for pediatric sedation during MRI.
  • To evaluate the efficacy and safety of the proposed equation.

Main Methods:

  • 180 children undergoing MRI were randomized into two groups: experimental (equation-based dosing) and control (conventional dosing).
  • Propofol induction and additional doses were administered.
  • Rescue propofol injections were given as needed.
  • Total induction dose, number of induction injections, and rescue doses were recorded.

Main Results:

  • The experimental group received a higher total induction dose but required fewer induction injections.
  • Significantly fewer rescue injections were administered in the experimental group.
  • The equation facilitated rapid sedation induction and reduced the need for rescue medication.

Conclusions:

  • The proposed propofol dosing equation effectively achieves faster sedation and minimizes rescue interventions in pediatric patients during MRI.
  • While promising, cautious implementation of the equation is recommended.
  • This equation may optimize propofol administration for pediatric procedural sedation.

Keywords:
childrenpropofolradiological examinationsedation

More Related Videos

Guidelines for Elective Pediatric Fiberoptic Intubation11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

17.7K
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.8K

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
188
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
147
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
273
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
468
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
64
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
382