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[Minor hepatitis probably caused by amodiaquine]
Bulletin De La Societe De Pathologie Exotique Et De Ses Filiales
|January 1, 1987
Summary
Amodiaquine, used for malaria prevention, may cause liver injury (hepatitis). Symptoms like nausea and jaundice resolved after switching to chloroquine, suggesting amodiaquine as the likely cause.
Area of Science:
- Hepatology
- Pharmacology
- Infectious Diseases
Background:
- Hepatitis is a significant concern in antimalarial drug use.
- Amodiaquine is a commonly used antimalarial drug, often taken prophylactically.
- Drug-induced liver injury can manifest in various forms.
Purpose of the Study:
- To investigate the potential hepatotoxicity of amodiaquine when used for malaria prophylaxis.
- To document clinical cases and outcomes associated with amodiaquine use.
Main Methods:
- Case series presentation of eight patients experiencing hepatitis.
- Clinical observation of symptoms, laboratory findings (transaminases), and treatment outcomes.
- In vitro testing was performed in one instance.
Main Results:
- Eight cases of probable amodiaquine-induced hepatitis were identified.
- Seven cases presented with mild symptoms including nausea, vomiting, and elevated transaminases (3-8 fold increase).
- One case developed jaundice; all symptoms resolved upon switching to chloroquine.
Conclusions:
- Amodiaquine, even at prophylactic doses, may be associated with liver injury.
- Hepatotoxicity from amodiaquine appears reversible upon drug discontinuation and substitution.
- Further investigation into amodiaquine's safety profile is warranted.