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Single-Atom Nanozymes: Fabrication, Characterization, Surface Modification and Applications of ROS Scavenging and
Haihan Song1, Mengli Zhang1, Weijun Tong1
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Molecules (Basel, Switzerland)
|September 9, 2022
Summary
Single-atom nanozymes (SAzymes) offer high atom utilization and enzyme-like activity, presenting a promising alternative to natural enzymes. This review covers their preparation, modification, and biomedical applications, particularly in reactive oxygen species scavenging and antibacterial uses.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Nanozymes, nanomaterials with enzyme-like catalytic properties, are emerging as alternatives to natural enzymes.
- Enhancing atom utilization efficiency in nanozymes is a key research focus.
- Single-atom nanozymes (SAzymes) represent a frontier due to their atomic-level design, high atom efficiency, and well-defined active sites.
Purpose of the Study:
- To review the preparation, characterization, and surface modification of single-atom nanozymes (SAzymes).
- To discuss the impact of surface modification on SAzyme activity.
- To summarize the biomedical applications of SAzymes, focusing on reactive oxygen species (ROS) scavenging and antibacterial uses.
Main Methods:
- Preparation of SAzymes via pyrolysis and defect engineering.
- Characterization techniques for SAzymes.
- Surface modification strategies and their influence on SAzyme activity.
Main Results:
- SAzymes can be synthesized with regulated activity through controlled preparation and defect engineering.
- Surface modification can modulate the catalytic activity of SAzymes.
- SAzymes demonstrate significant potential in biomedical applications, including ROS scavenging and antibacterial therapies.
Conclusions:
- SAzymes offer superior atom utilization and tunable properties compared to traditional nanozymes.
- Further research into SAzyme preparation, modification, and application holds significant promise for the biomedical field.
- Addressing current challenges and exploring new opportunities will drive the advancement of SAzyme technology.
