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Combination Anticancer Therapies Using Selected Phytochemicals.

Wamidh H Talib1, Dima Awajan1, Reem Ali Hamed1

  • 1Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931-166, Jordan.

Molecules (Basel, Switzerland)
|September 9, 2022
PubMed
Summary
This summary is machine-generated.

Plant-derived natural products offer promising, less toxic alternatives for cancer treatment. This review analyzes phytochemical anticancer mechanisms and combination therapies, aiding research into novel cancer medicines.

Keywords:
alternative anticancer therapycancercurcuminnatural productsresveratrol

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Area of Science:

  • Oncology
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Cancer remains a leading global health challenge, significantly impacting life expectancy.
  • Conventional chemotherapy often exhibits toxicity and lacks selectivity, necessitating alternative treatments.
  • Plant-derived natural products show significant potential in cancer therapy due to diverse mechanisms, structures, availability, and lower toxicity.

Purpose of the Study:

  • To analyze the anticancer mechanisms of prevalent phytochemicals.
  • To discuss the efficacy of combining natural products with each other or with chemotherapeutic drugs.
  • To provide a foundation for advancing research in alternative anticancer drug development.

Main Methods:

  • Comprehensive literature review of existing research on phytochemicals and cancer.
  • Analysis of documented anticancer mechanisms of common plant-derived compounds.
  • Evaluation of studies reporting on combination therapies involving natural products and conventional drugs.

Main Results:

  • Phytochemicals exhibit multiple anticancer mechanisms, including antiproliferative, apoptotic, anti-angiogenic, and antioxidant effects.
  • Combinations of natural products or natural products with chemotherapeutics can enhance efficacy and potentially reduce side effects.
  • Synergistic effects observed in combined therapies warrant further investigation.

Conclusions:

  • Plant-derived natural products represent a valuable resource for developing novel, safer anticancer agents.
  • Combination strategies hold promise for overcoming drug resistance and improving treatment outcomes.
  • Further research is crucial for translating these findings into clinical applications for cancer patients.