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Related Concept Videos

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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Aug 29, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

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Small-Molecule PROTACs for Cancer Immunotherapy.

Zefan Liu1, Yajun Zhang1, Yucheng Xiang1

  • 1West China (Airport) Hospital, Sichuan University, Chengdu 610047, China.

Molecules (Basel, Switzerland)
|September 9, 2022
PubMed
Summary

Small-molecule drugs, like proteolysis targeting chimeras (PROTACs), can overcome limitations of macromolecular drugs in cancer immunotherapy. This review explores PROTAC applications for immuno-oncology targets to advance tumor treatment.

Keywords:
proteolysis targeting chimerasmall molecule inhibitorstargeted protein degradationtumor immunotherapytumor microenvironment

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Area of Science:

  • Oncology
  • Immunology
  • Medicinal Chemistry

Background:

  • Macromolecular drugs face challenges in tumor immunotherapy due to poor physicochemical properties.
  • Small-molecule compounds offer a viable solution to these limitations.
  • Proteolysis targeting chimeras (PROTACs) represent a novel small-molecule modality targeting protein degradation.

Purpose of the Study:

  • To review existing and potential immunological targets for PROTAC technology in cancer immunotherapy.
  • To identify opportunities for developing small-molecule-based tumor immunotherapies.
  • To explore novel strategies for enhancing PROTAC-mediated protein degradation efficiency.

Main Methods:

  • Comprehensive literature review of PROTAC technology and its application in immuno-oncology.
  • Analysis of well-studied, less-developed, and unexplored immunological targets for PROTACs.
  • Discussion of emerging directions in PROTAC design for improved efficacy.

Main Results:

  • PROTACs show significant potential for targeting tumor survival proteins but are underexplored in immuno-oncology.
  • Several immunological targets are identified as promising for PROTAC-based cancer immunotherapy.
  • Novel approaches to enhance protein degradation efficiency are proposed.

Conclusions:

  • PROTAC technology offers a promising avenue for developing novel small-molecule cancer immunotherapies.
  • Expanding PROTAC applications to immuno-oncology targets can provide new therapeutic options.
  • Future research should focus on optimizing PROTAC design for enhanced degradation and broader applicability.