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Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing: Review on Recent Progress
Manoj Singh1, Vanita Thakur1, Vikas Kumar1
1Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India.
Abstract:
Wounds are structural and functional disruptions of skin that occur because of trauma, surgery, acute illness, or chronic disease conditions. Chronic wounds are caused by a breakdown in the finely coordinated cascade of events that occurs during healing. Wound healing is a long process that split into at least three continuous and overlapping processes: an inflammatory response, a proliferative phase, and finally the tissue remodeling. Therefore, these processes are extensively studied to develop novel therapeutics in order to achieve maximum recovery with minimum scarring. Several growth hormones and cytokines secreted at the site of lesions tightly regulates the healing processes. The traditional approach for wound management has been represented by topical treatments. Metal nanoparticles (e.g., silver, gold and zinc) are increasingly being employed in dermatology due to their favorable effects on healing, as well as in treating and preventing secondary bacterial infections. In the current review, a brief introduction on traditional would healing approach is provided, followed by focus on the potential of wound dressing therapeutic techniques functionalized with Ag-NPs.
Insights
This review explores how metal nanoparticles, particularly silver nanoparticles (Ag-NPs), can enhance wound healing. Ag-NPs show promise in improving recovery and preventing infections in chronic wounds.
Area of Science:
- Dermatology and Regenerative Medicine
Background:
- Wound healing involves complex inflammatory, proliferative, and remodeling phases, often disrupted in chronic wounds.
- Traditional wound management relies on topical treatments, but novel therapeutic strategies are needed for optimal recovery and scar reduction.
Purpose of the Study:
- To review traditional wound healing approaches.
- To highlight the therapeutic potential of wound dressings functionalized with silver nanoparticles (Ag-NPs).
Main Methods:
- Literature review focusing on wound healing processes and nanoparticle applications in dermatology.
- Analysis of the role of growth hormones and cytokines in wound repair.
- Examination of metal nanoparticles, specifically Ag-NPs, for wound management.
Main Results:
- Metal nanoparticles, including silver, gold, and zinc, demonstrate beneficial effects on wound healing.
- Ag-NPs are effective in treating and preventing secondary bacterial infections in wounds.
- Functionalized wound dressings offer a promising therapeutic avenue.
Conclusions:
- Silver nanoparticles represent a significant advancement in therapeutic wound dressings.
- Ag-NP-functionalized dressings hold potential for improved chronic wound management and infection control.
