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Pre-clinical models to study abnormal uterine bleeding (AUB)
Aleksandra O Tsolova1, Rocío Martínez Aguilar1, Jacqueline A Maybin1
1MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Ebiomedicine
|September 9, 2022
Summary
Abnormal Uterine Bleeding (AUB) research is hindered by a lack of reliable pre-clinical models. This review examines current in vitro, ex vivo, and in vivo models for studying AUB pathophysiology and developing new therapies.
Area of Science:
- Reproductive medicine
- Pre-clinical research models
- Gynecological disorders
Background:
- Abnormal Uterine Bleeding (AUB) is a prevalent condition impacting women's quality of life and public health.
- AUB leads to substantial medical, social, and economic burdens.
- Progress in understanding AUB pathophysiology and developing therapies is slow due to inadequate pre-clinical models.
Purpose of the Study:
- To review existing laboratory-based pre-clinical models for studying AUB.
- To discuss the application of these models in AUB research.
- To highlight the advantages and limitations of various AUB pre-clinical models.
Main Methods:
- Review of current literature on pre-clinical models for AUB.
- Description of human and animal in vitro models.
- Description of ex vivo and in vivo models.
Main Results:
- Various pre-clinical models (in vitro, ex vivo, in vivo) are available for AUB research.
- Each model type presents unique advantages and limitations.
- Current models offer opportunities to study AUB pathophysiology.
Conclusions:
- Reliable pre-clinical models are crucial for advancing AUB research.
- A comprehensive understanding of model limitations is necessary for effective AUB therapy development.
- Further development of robust pre-clinical models is needed to accelerate progress in treating AUB.
