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Updated: Aug 29, 2025
11:27
A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
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Akt isoforms in the immune system.
Mireia Guerau-de-Arellano1,2,3,4,5, Zayda L Piedra-Quintero1, Philip N Tsichlis5,6
1School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Frontiers in Immunology
|September 9, 2022
Summary
This review explores the crucial roles of the three Akt isoforms (Akt1, Akt2, and Akt3) in both innate and adaptive immune cells, highlighting their importance in immune cell development and function.
Area of Science:
- Immunology
- Molecular Biology
- Cell Signaling
Background:
- The serine-threonine kinase Akt, activated by PI3K, has three distinct isoforms: Akt1, Akt2, and Akt3.
- Akt expression is significant in most immune cells, both at baseline and upon activation.
- Akt is highly expressed in innate immune cells and plays vital roles in both innate and adaptive immunity.
Purpose of the Study:
- To review the known functions of Akt in innate and adaptive immune cells.
- To delineate the overlapping and distinct roles of Akt1, Akt2, and Akt3 in immune cell biology.
Main Methods:
- Literature review of existing research on Akt signaling in immune cells.
- Analysis of studies investigating the expression and function of Akt isoforms in various immune cell types.
Main Results:
- Akt isoforms are critical for the development and effector functions of both innate and adaptive immune cells.
- Specific roles and expression patterns of Akt1, Akt2, and Akt3 vary across different immune cell populations.
- Akt signaling is integral to immune cell homeostasis and response.
Conclusions:
- Akt signaling is a key regulator of immune cell function.
- Understanding the distinct roles of Akt isoforms provides insights into immune system regulation.
- Further research into Akt isoform-specific functions can inform therapeutic strategies for immune-related diseases.
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