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Pan-Cancer Analysis Reveals the Relation between TRMT112 and Tumor Microenvironment
Haitao Xu1, Caihong Jiang2, Fusheng Yao1
1Department of Hematology, Anqing Municipal Hospital, Anqing Medical Center Affiliated to Anhui Medical University, Anqing, China.
Abstract:
Dysregulated epigenetic modifications play a critical role in cancer development where TRMT112 is a member of the transfer RNA (tRNA) methyltransferase family. Till now, no studies have revealed the linkage between TRMT112 expression and diverse types of tumors. Based on TCGA data, we first probed into the relation between TRMT112 and prognosis and the potential role of TRMT112 in tumor microenvironment across 33 types of tumor. TRMT112 presented with increased expression in most cancers, which was significantly prognostic. Furthermore, TRMT112 was associated with tumor-associated fibroblasts in a variety of cancers. Additionally, a positive relationship was identified between TRMT112 expression and multiple tumor-related immune infiltrations, such as dendritic cells, CD8+ T cells, macrophages, CD4+ T cells, neutrophils, and B cells in lung adenocarcinoma and breast invasive carcinoma. In summary, our results suggest that TRMT112 might be a potential prognostic predictor of cancers and involved in regulating multiple cancer-related immune responses to some extent.
Insights
TRMT112, a transfer RNA (tRNA) methyltransferase, is upregulated in most cancers and linked to poor prognosis. Its expression correlates with tumor-associated fibroblasts and immune cell infiltration, suggesting a role in cancer progression and immune response.
Area of Science:
- Oncology
- Epigenetics
- Molecular Biology
Background:
- Epigenetic dysregulation is crucial in cancer development.
- TRMT112 is a member of the transfer RNA (tRNA) methyltransferase family.
- The role of TRMT112 in various cancers and its prognostic significance remain largely unexplored.
Purpose of the Study:
- To investigate the association between TRMT112 expression and cancer prognosis across 33 tumor types.
- To explore the potential role of TRMT112 in the tumor microenvironment.
- To analyze the relationship between TRMT112 and tumor-infiltrating immune cells.
Main Methods:
- Utilized The Cancer Genome Atlas (TCGA) database for comprehensive analysis.
- Examined TRMT112 expression levels in tumor tissues and normal tissues.
- Correlated TRMT112 expression with patient survival data and tumor microenvironment components.
Main Results:
- TRMT112 expression was significantly increased in the majority of analyzed cancers.
- Elevated TRMT112 expression was associated with poorer prognosis across multiple cancer types.
- TRMT112 showed correlations with tumor-associated fibroblasts and various immune cell infiltrations, including CD8+ T cells, macrophages, and dendritic cells, particularly in lung adenocarcinoma and breast invasive carcinoma.
Conclusions:
- TRMT112 may serve as a valuable prognostic biomarker for diverse cancers.
- TRMT112 expression is implicated in modulating the tumor microenvironment and influencing anti-tumor immune responses.
- Further research into TRMT112's functional role in cancer immunity is warranted.
