Pan-Cancer Analysis Reveals the Relation between TRMT112 and Tumor Microenvironment

Area of Science:

• Oncology
• Epigenetics
• Molecular Biology

Background:

• Epigenetic dysregulation is crucial in cancer development.
• TRMT112 is a member of the transfer RNA (tRNA) methyltransferase family.
• The role of TRMT112 in various cancers and its prognostic significance remain largely unexplored.

Purpose of the Study:

• To investigate the association between TRMT112 expression and cancer prognosis across 33 tumor types.
• To explore the potential role of TRMT112 in the tumor microenvironment.
• To analyze the relationship between TRMT112 and tumor-infiltrating immune cells.

Main Methods:

• Utilized The Cancer Genome Atlas (TCGA) database for comprehensive analysis.
• Examined TRMT112 expression levels in tumor tissues and normal tissues.
• Correlated TRMT112 expression with patient survival data and tumor microenvironment components.

Main Results:

• TRMT112 expression was significantly increased in the majority of analyzed cancers.
• Elevated TRMT112 expression was associated with poorer prognosis across multiple cancer types.
• TRMT112 showed correlations with tumor-associated fibroblasts and various immune cell infiltrations, including CD8+ T cells, macrophages, and dendritic cells, particularly in lung adenocarcinoma and breast invasive carcinoma.

Conclusions:

• TRMT112 may serve as a valuable prognostic biomarker for diverse cancers.
• TRMT112 expression is implicated in modulating the tumor microenvironment and influencing anti-tumor immune responses.
• Further research into TRMT112's functional role in cancer immunity is warranted.