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Updated: Aug 29, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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CircSMARCA5: A key circular RNA in various human diseases
Yi Zhu1, Gaozhen Huang1, Shihao Li1
1Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Frontiers in Genetics
|September 9, 2022
Summary
Circular RNAs (circRNAs) are stable molecules involved in various diseases. CircSMARCA5, a specific circRNA, shows potential as a diagnostic and prognostic biomarker in multiple cancers.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Circular RNAs (circRNAs) are endogenous noncoding RNA molecules with unique stability and tissue specificity.
- circRNAs play critical roles in disease pathogenesis, including cancer, by regulating gene expression.
- CircSMARCA5 is a notable circRNA implicated in various noninfectious diseases, particularly cancers.
Purpose of the Study:
- To review the biological roles and molecular mechanisms of circSMARCA5 in diverse diseases.
- To evaluate circSMARCA5 as a potential diagnostic and prognostic biomarker in malignant tumors.
Main Methods:
- Literature review of studies investigating circSMARCA5.
- Analysis of circSMARCA5's role in disease development and progression.
- Meta-analysis of circSMARCA5 expression in relation to patient prognosis and tumor stage.
Main Results:
- CircSMARCA5 is dysregulated in numerous cancers, including gastric, breast, and liver cancers.
- CircSMARCA5 functions primarily as a microRNA (miRNA) sponge, modulating downstream gene expression.
- Meta-analysis revealed a significant correlation between circSMARCA5 expression, patient prognosis, and tumor TNM stage.
Conclusions:
- CircSMARCA5 exhibits significant roles in the development and progression of various cancers.
- CircSMARCA5 holds promise as a valuable biomarker for cancer diagnosis and predicting patient outcomes.
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