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Updated: Aug 29, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.3K

CircSMARCA5: A key circular RNA in various human diseases

Yi Zhu1, Gaozhen Huang1, Shihao Li1

  • 1Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Frontiers in Genetics
|September 9, 2022
PubMed

Insights

Circular RNAs (circRNAs) are stable molecules involved in various diseases. CircSMARCA5, a specific circRNA, shows potential as a diagnostic and prognostic biomarker in multiple cancers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are endogenous noncoding RNA molecules with unique stability and tissue specificity.
  • circRNAs play critical roles in disease pathogenesis, including cancer, by regulating gene expression.
  • CircSMARCA5 is a notable circRNA implicated in various noninfectious diseases, particularly cancers.

Purpose of the Study:

  • To review the biological roles and molecular mechanisms of circSMARCA5 in diverse diseases.
  • To evaluate circSMARCA5 as a potential diagnostic and prognostic biomarker in malignant tumors.

Main Methods:

  • Literature review of studies investigating circSMARCA5.
  • Analysis of circSMARCA5's role in disease development and progression.
  • Meta-analysis of circSMARCA5 expression in relation to patient prognosis and tumor stage.

Main Results:

  • CircSMARCA5 is dysregulated in numerous cancers, including gastric, breast, and liver cancers.
  • CircSMARCA5 functions primarily as a microRNA (miRNA) sponge, modulating downstream gene expression.
  • Meta-analysis revealed a significant correlation between circSMARCA5 expression, patient prognosis, and tumor TNM stage.

Conclusions:

  • CircSMARCA5 exhibits significant roles in the development and progression of various cancers.
  • CircSMARCA5 holds promise as a valuable biomarker for cancer diagnosis and predicting patient outcomes.
Keywords:
biomarkercancercircSMARCA5circular RNAmiRNA sponge

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