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The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients
Jianpeng Yu1, Qi Zhou1, Ying Xu1
1Department of Nephrology, Shanghai Changhai Hospital, Shanghai, People's Republic of China.
International Journal of General Medicine
|September 9, 2022
Summary
Serum folate levels are linked to residual renal function in continuous ambulatory peritoneal dialysis patients. Lower folate levels correlate with poorer kidney function, suggesting a potential role for supplementation.
Area of Science:
- Nephrology
- Internal Medicine
- Nutritional Science
Background:
- Continuous ambulatory peritoneal dialysis (CAPD) is a common treatment for end-stage renal disease.
- Nutritional status, including folate levels, may impact patient outcomes in CAPD.
- Understanding factors affecting residual renal function (RRF) is crucial for managing CAPD patients.
Purpose of the Study:
- To investigate the relationship between serum folate (FA) levels and residual renal function (RRF) in CAPD patients.
- To determine if FA deficiency is associated with impaired RRF in this population.
Main Methods:
- A cohort of 180 hospitalized CAPD patients was analyzed.
- Patients were categorized into FA deficiency and non-deficiency groups based on serum FA levels.
- Clinical data, including various biochemical markers and dialysis adequacy parameters (Kt/V, creatinine clearance), were collected and statistically analyzed.
Main Results:
- Patients with FA deficiency exhibited higher peritoneal Kt/V, cystatin C (cytC), and serum creatinine (Scr) levels.
- Conversely, the residual kidney Kt/V was significantly lower in the FA-deficient group.
- Serum FA levels showed a significant positive correlation with residual kidney Kt/V and negative correlations with peritoneal Kt/V, cytC, and Scr.
Conclusions:
- A significant relationship exists between serum folate levels and residual renal function in CAPD patients.
- FA deficiency is associated with poorer RRF in this cohort.
- Further prospective studies are warranted to explore the impact of folate supplementation on maintaining RRF during peritoneal dialysis.
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