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VTE Prophylaxis Therapy: Clinical Practice vs Clinical Guidelines.

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Area of Science:

  • Internal Medicine
  • Clinical Pharmacy
  • Public Health

Background:

  • Venous thromboembolism (VTE) is a major preventable complication in hospitalized individuals.
  • Adherence to established VTE prophylaxis guidelines is crucial for patient safety.

Purpose of the Study:

  • To evaluate adherence to VTE prophylaxis guidelines in a Palestinian teaching hospital.
  • To assess the appropriateness of VTE prophylaxis in medically ill patients.

Main Methods:

  • A cross-sectional, retrospective study of 408 hospitalized patients over 24 hours.
  • Utilized Padua and IMPROVE risk assessment models to evaluate VTE and bleeding risks.
  • Medical records were analyzed for prophylaxis administration and adherence to guidelines.

Main Results:

  • Only 54.4% of patients received thromboprophylaxis.
  • Among high-risk patients (Padua score ≥ 4), only 60.3% received appropriate pharmacological prophylaxis.
  • A significant proportion of patients (80.18%) received inappropriate VTE prophylaxis.

Conclusions:

  • VTE prophylaxis management in the studied hospital was largely inappropriate.
  • Adopting VTE risk stratification tools is essential for improving prophylaxis and preventing complications.
  • Clinical guidelines and risk assessment models are vital for optimizing VTE prevention strategies.