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Metabolic acidosis post kidney transplantation
1Division of Nephrology, University of Rochester Medical Center, Rochester, NY, United States.
Frontiers in Physiology
|September 9, 2022
Summary
Metabolic acidosis persists in some kidney transplant recipients despite improved kidney function. This review explores causes and consequences, highlighting potential benefits of correction therapies.
Area of Science:
- Nephrology
- Transplantation Medicine
- Acid-Base Balance
Background:
- Metabolic acidosis is a frequent complication in chronic kidney disease (CKD).
- While kidney transplantation often corrects metabolic acidosis, some recipients experience persistent acidosis and related complications.
- Understanding the unique factors contributing to acidosis in transplant recipients is crucial.
Purpose of the Study:
- To review the pathogenesis of metabolic acidosis in kidney transplant recipients.
- To summarize the clinical consequences of persistent metabolic acidosis post-transplantation.
- To discuss potential therapeutic strategies for correcting metabolic acidosis in this population.
Main Methods:
- Literature review of published evidence.
- Synthesis of data on acidosis causes and effects in kidney transplant patients.
- Analysis of transplant-specific factors contributing to metabolic acidosis.
Main Results:
- Metabolic acidosis in kidney transplant recipients stems from both CKD-related and transplant-specific factors.
- Transplant-specific causes include donor factors, recipient issues, immune responses, and immunosuppressants.
- Persistent acidosis can lead to significant morbidities in kidney allograft recipients.
Conclusions:
- Metabolic acidosis remains a challenge for a subset of kidney transplant recipients.
- Further research into transplant-specific causes is warranted.
- Alkali therapy and dietary interventions show promise for correcting acidosis and improving outcomes, with clinical trials anticipated.
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