[Phage therapy, an additional strategy against multidrug-resistant bacteria]

Area of Science:

• Microbiology and Virology
• Infectious Diseases
• Bacteriology

Background:

• Bacteriophages (phages) are viruses that specifically infect bacteria.
• Phage therapy, utilizing phages against bacterial infections, emerged in the early 20th century but was superseded by antibiotics.
• The rise of multidrug-resistant bacteria has reignited interest in phage therapy as a viable alternative.

Purpose of the Study:

• To reintroduce phage therapy to the medical community.
• To detail the mechanisms of action, clinical applications, and practical use of phages in Belgium.
• To outline future challenges and opportunities for phage therapy.

Main Methods:

• Literature review of phage therapy mechanisms and historical context.
• Analysis of clinical aspects and case studies.
• Examination of practical modalities for phage therapy implementation in Belgium.

Main Results:

• Phages offer a specific mechanism for targeting bacterial infections.
• Renewed interest is driven by the urgent need for alternatives to antibiotics.
• The review provides a comprehensive overview of phage therapy's potential.

Conclusions:

• Phage therapy presents a promising solution to the challenge of antibiotic resistance.
• Further research and clinical implementation are necessary to fully realize its potential.
• The review serves as a guide for the medical profession regarding phage therapy in Belgium.