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Examining the Association Between MIS-C and the Child Opportunity Index at a Single Center

Jordan Tyris1,2, Kaitlyn Boggs3, James Bost1

  • 1Division of Hospital Medicine.

Hospital Pediatrics
|September 9, 2022
PubMed

Insights

Children in areas with low Child Opportunity Index (COI) scores face higher risks for multisystem inflammatory syndrome in childhood (MIS-C). This highlights how neighborhood factors influence MIS-C diagnosis in children.

Area of Science:

  • Pediatric Health
  • Environmental Epidemiology
  • Social Determinants of Health

Background:

  • Multisystem inflammatory syndrome in childhood (MIS-C) is a serious condition affecting children.
  • Understanding risk factors for MIS-C is crucial for public health interventions.
  • Socioeconomic and environmental factors may play a role in MIS-C development.

Purpose of the Study:

  • To investigate the association between the Child Opportunity Index (COI) and MIS-C diagnosis.
  • To determine if neighborhood-level opportunity impacts MIS-C risk in hospitalized children.

Main Methods:

  • Retrospective case-control study of children hospitalized between March 2020 and June 2021.
  • Compared 111 children diagnosed with MIS-C against 61 controls with alternative diagnoses.
  • Utilized census tract-level COI based on patient addresses as the exposure variable.

Main Results:

  • A significant difference in overall COI distribution was observed between MIS-C cases and controls (P = .03).
  • Children in very low to low overall COI census tracts had significantly higher odds of MIS-C diagnosis (OR = 2.82).
  • Children in very low to low health/environment COI census tracts also had significantly higher odds of MIS-C diagnosis (OR = 4.69).

Conclusions:

  • Child Opportunity Index is associated with MIS-C diagnosis in hospitalized children.
  • Place-based determinants, reflected by COI, significantly contribute to MIS-C development.
  • This suggests that neighborhood conditions are important factors in pediatric MIS-C risk.
Abstract

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