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Morphing-to-Adhesion Polysaccharide Hydrogel for Adaptive Biointerfaces.

Shanshan Wang1,2, Qilong Zhao1, Jinhong Li2

  • 1Institute of Biomedical & Health Engineering, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518035, China.

ACS Applied Materials & Interfaces
|September 9, 2022
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Summary
This summary is machine-generated.

This study introduces a novel bilayer hydrogel adaptive biointerface (HAB) that conforms to complex tissue shapes. HABs improve medical implant integration by enhancing bioactivity and stable fixation, overcoming limitations of current synthetic hydrogels.

Keywords:
adaptive biointerfacebioactivitybioadhesionhydrogelshape morphing

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Medical Device Development

Background:

  • Reliable medical implant function requires biocompatible biointerfaces for seamless integration.
  • Existing synthetic hydrogel biointerfaces face challenges in adaptability, bioactivity, and fixation, especially for curved tissues.

Purpose of the Study:

  • To develop an adaptive biointerface (HAB) using polysaccharide derivatives for improved medical implant biointegration.
  • To address limitations of current biointerfaces in conforming to and stably attaching to tissues with large surface curvatures.

Main Methods:

  • Fabrication of a bilayer hydrogel adaptive biointerface (HAB) from N-hydroxysuccinimide (NHS) ester-activated alginate and chitosan.
  • Utilizing differential swelling and interfacial covalent linkages for water-induced shape morphing and adhesion.
  • Evaluating HAB's bioactivity, geometrical adaptability to various tubular tissues, and mechanical stability under physiological conditions.

Main Results:

  • The polysaccharide-based HAB demonstrated programmed shape morphing into sealed tubes with tunable diameters via water-induced adhesion.
  • HAB exhibited enhanced bioactivity, promoting cellular focal adhesion and intercellular junction formation.
  • Achieved versatile geometrical adaptability to diverse tubular tissues (surface curvatures 2.8 × 10^2–1.3 × 10^3 m^-1) and mechanical stability (blood flow 85 mm·s^-1).

Conclusions:

  • The developed HAB overcomes limitations in bioactivity and biointegration for tissues with large surface curvatures.
  • This adaptive biointerface shows significant promise for advancing medical implant design and reliability.