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A Microfluidic Technique to Probe Cell Deformability
Published on: September 3, 2014
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Mechanism and Effects of Cellular Creep in a Microfluidic Filter
Boran Zhang1,2, Siyuan Zou2, Wenshuai Wu3
1School of Electrical and Electronic Engineering, Nanyang Technological University, 639798 Singapore.
The Journal of Physical Chemistry Letters
|September 9, 2022
Summary
Viscoelastic biomicroparticles exhibit creep deformation, making them harder to release from microfluidic filters compared to elastic particles. This study quantifies cellular creep in filtration applications.
Area of Science:
- Biophysics
- Microfluidics
- Cellular Mechanics
Background:
- Biomicroparticles (proteins, bacteria, cells) are viscoelastic, impacting microfluidic performance.
- Quantitative understanding of cellular viscoelastic creep in applications is lacking.
Purpose of the Study:
- To investigate cellular deformation evolution in microfluidic filter units.
- To quantitatively describe viscoelastic creep using maximum surface displacement and volumetric strain.
- To analyze the influence of flow conditions and particle characteristics on creep.
Main Methods:
- Utilized a multiphysics numerical model to simulate cellular deformation.
- Identified key variables (maximum surface displacement, volumetric strain) for quantitative analysis.
- Conducted experimental validation using a Giardia concentration filtration system.
Main Results:
- Revealed a general cellular creep deformation process during pore trapping.
- Demonstrated that creep deformation is time-accumulated.
- Showed experimental results align with numerical analysis.
Conclusions:
- Viscoelastic particle trapping in pores is governed by creep deformation.
- Cellular material, including cells and microbes, is more difficult to release from filters due to creep.
- The study provides quantitative insights into cellular viscoelasticity in microfluidic filtration.
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