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Related Experiment Video

Updated: Aug 29, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

Library Synthesis: Building Block Selection, Handling, and Tracking.

Katelyn J Billings¹, Melissa C Grenier-Davies²

¹Relay Therapeutics, Cambridge, MA, USA. kbillings@relaytx.com.

Methods in Molecular Biology (Clifton, N.J.)

|September 9, 2022

Summary

This summary is machine-generated.

Selecting and handling small molecule building blocks is key for successful DNA-encoded libraries. Proper strategies ensure high-quality hits and accurate synthesis for drug discovery.

Keywords:

2D barcoded tubes Building blocks DNA-encoded library Diversity selection Library optimization Property filters Reactivity Small molecules

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Last Updated: Aug 29, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

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Published on: September 6, 2019

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Area of Science:

Medicinal Chemistry
Synthetic Chemistry
Drug Discovery

Background:

DNA-encoded libraries (DELs) are powerful tools for identifying drug leads.
The quality of small molecule building blocks directly influences DEL screening efficiency.
Effective sample management is essential for subsequent synthesis and validation.

Purpose of the Study:

To outline strategies for selecting optimal small molecule building blocks for DELs.
To provide best practices for handling and tracking samples used in DEL synthesis and validation.

Main Methods:

Review of building block selection methodologies in DEL construction.
Discussion of sample handling and tracking protocols for library synthesis.
Guidance on ensuring synthetic map accuracy for follow-up studies.

Main Results:

Identification of key factors influencing building block selection for DELs.
Establishment of best practices for sample management in DEL workflows.
Emphasis on the link between building block choice, assay quality, and synthetic success.

Conclusions:

Strategic building block selection is paramount for high-quality DEL screening.
Robust sample handling and tracking are critical for efficient validation and synthesis.
Implementing these practices enhances the overall success rate of DNA-encoded library campaigns.