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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Updated: Aug 29, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Geriatric syndromes in a centenarians population.

Cécile Croize-Pourcelet1, Emilie Nouguerede1, Dominique Rey1

  • 1Internal Medicine, Geriatric and Therapeutic Unit, Marseille University Hospital (AP-HM), 270 Boulevard de Sainte Marguerite, 13009, Marseille, France.

Aging Clinical and Experimental Research
|September 9, 2022
PubMed
Summary

Centenarians, though models of successful aging, universally experience dependency and geriatric syndromes. Maintaining them at home requires significant support systems, including caregivers and technical aids.

Keywords:
CentenariansGeriatric syndromesNursing homesPrivate housing

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Area of Science:

  • Gerontology
  • Geriatric Medicine
  • Public Health

Background:

  • Centenarians often develop age-related diseases later than younger individuals.
  • Understanding the health status of the oldest old is crucial for public health initiatives.

Purpose of the Study:

  • To assess geriatric syndromes in centenarians residing in Marseille in 2020.
  • To describe the characteristics and health needs of this extreme aging population.

Main Methods:

  • An observational, preliminary study involving centenarians from general practitioners' patient databases in Marseille.
  • Data collection focused on dependency, mobility, cognitive function, and comorbidities.

Main Results:

  • Twenty-two centenarians (77.3% female) were included; 13 lived in nursing homes (NH) and 9 in private housing (PH).
  • All participants were dependent for daily living activities, with 78.9% using walkers.
  • Nursing home residents exhibited more cognitive impairments and comorbidities but fewer hospitalizations than those in private housing.

Conclusions:

  • All studied centenarians experienced dependency and at least one geriatric syndrome, despite representing successful aging.
  • Home-based care for centenarians necessitates robust technical support, multidisciplinary professional involvement, and strong family support networks.