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Updated: Aug 29, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING
Takahiro Wada1, Tetsuhiro Kinugawa2, Satoshi Tanaka3
1Department of Pure and Applied Physics, Kansai University, 3-3-35 Yamate-cho, Suita 564-8680, Japan.
Abstract:
The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage-Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time. Radiation-induced aging for acute and chronic exposures is described using age-specific cancer incidence rates as a measure of aging. It shows that accelerated aging is related to the dose rate, whereas premature aging is related to the cumulative dose, providing a simple and natural interpretation of radiation-induced aging. The usefulness of this approach is demonstrated by applying the formula to cancer prevalence data from mice chronically exposed to low dose-rate radiation.
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