Related Experiment Video
Updated: Aug 29, 2025

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
Vogt-Koyanagi-Harada Disease in Pre-school Children
Soumen Sadhu1, Parthopratim Dutta Majumder2, Mauli Shah2
1Department of Optometry, Medical Research Foundation, Sankara Nethralaya, Chennai, India.
Insights
Pediatric Vogt Koyanagi Harada (VKH) disease in a 4-year-old boy required aggressive, multidisciplinary management including corticosteroids, immunosuppressants, and glaucoma surgery. This approach ultimately improved visual acuity to 20/60.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Immunology
Background:
- Vogt Koyanagi Harada (VKH) disease is a rare, systemic inflammatory condition affecting ocular and neurological tissues.
- VKH disease in preschool children presents unique management challenges due to its aggressive nature and potential for severe visual impairment.
Purpose:
To report the management and outcome of VKH disease in a 4-year-old boy with a review of literature on VKH in preschool children (3 to 5 years).
Method:
Retrospective chart and literature review.
Result:
A 4-year-old boy presented with visual acuity of light perception in both eyes with panuveitis, secondary cataracts and intraocular pressure (IOP) of ≥40 mmHg in both eyes. He was started on oral corticosteroid, immunosuppressive and underwent glaucoma filtering surgery and lensectomy with vitrectomy after adequate control of intraocular inflammation. Over time his IOP was again uncontrolled even with maximum anti-glaucoma medications, and he underwent Ahmed glaucoma valve (AGV) implantation, and he gained a visual acuity of 20/60 in both eyes with aphakic correction at the last visit.
Conclusion:
Paediatric VKH follows an aggressive disease phase and requires a comprehensive multispeciality management approach.
Related Concept Videos
Sex-linked Disorders
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Teratogenicity
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

