Related Experiment Video
Updated: Aug 29, 2025
07:09
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
2.0K
Heart failure with recovered ejection fraction: Current understanding and future prospects.
1Department of Cardiology, Affiliated Hospital of Putian University, Fujian, China.
The American Journal of the Medical Sciences
|September 9, 2022
Summary
Heart failure with recovered ejection fraction (HFrecEF) represents a distinct patient group with improved outcomes but persistent cellular changes. Further research is needed to fully understand and manage this condition.
Area of Science:
- Cardiology
- Heart Failure Research
Background:
- Heart failure with reduced ejection fraction (HFrEF) can improve, but some patients experience incomplete recovery.
- Persistent cellular and molecular changes exist even with improved ejection fraction.
Purpose of the Study:
- To define and review the current understanding of heart failure with recovered ejection fraction (HFrecEF).
- To highlight the need for more research into the natural history and management of HFrecEF.
Main Methods:
- Literature review of existing studies on HFrecEF.
- Analysis of microscopic and clinical data related to recovered ejection fraction.
Main Results:
- Patients with HFrecEF show milder symptoms and better outcomes than those with persistent HFrEF.
- Despite reverse remodeling, cardiomyocyte morphology and gene expression abnormalities persist.
Conclusions:
- HFrecEF is a newly defined category requiring further investigation.
- Accurate risk assessment and clinical management strategies for HFrecEF are currently limited due to data scarcity.
More Related Videos
09:20Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
6.6K
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
8.6K
Related Concept Videos
01:17Pathophysiology of Heart Failure
1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
01:29Heart Failure II: Pathophysiology
31
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
31
01:30Heart Failure IV: Classification and Diagnostic Evaluation
27
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
27
01:30Heart Failure V: Medical Management
21
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
21
01:27Heart Failure I: Introduction
45
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
45
01:30Cardiomyopathy II: Dilated Cardiomyopathy
19
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
19