Related Experiment Video
Updated: Aug 29, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
Impact of N6-methyladenosine (m6A) modification on immunity
Raghda A Elsabbagh1, Mona Rady2,3, Carsten Watzl4
1Biochemistry Department, Faculty of Pharmacy and Biotechnology, The German University in Cairo, Cairo, Egypt.
Abstract:
N6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m6A modification has been implicated in various human diseases. Thus, m6A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m6A in regulating immune cell functions and immune responses. Video abstract.
Related Concept Videos
RNA Editing
Biosynthesis of Nucleic Acids
RNA Stability
Epigenetic Regulation
X-chromosome...
Pre-mRNA Processing: Modification of pre-mRNA Ends
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
MicroRNAs

