Related Experiment Video
Updated: Aug 29, 2025
11:44
Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
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Alternative pathways driven by STING: From innate immunity to lipid metabolism
Isabelle K Vila1, Soumyabrata Guha1, Joanna Kalucka2
1Institut de Génétique Humaine, Univ Montpellier, CNRS, Montpellier, France.
Cytokine & Growth Factor Reviews
|September 9, 2022
Summary
The Stimulator of Interferon Genes (STING) protein initiates immune responses. Emerging research reveals STING also regulates metabolic pathways, impacting homeostasis and disease.
Area of Science:
- Immunology
- Metabolic regulation
- Molecular biology
Background:
- Stimulator of Interferon Genes (STING) is a key adaptor protein in innate immunity.
- STING initiates type I interferon and inflammatory signaling pathways.
- Cytosolic nucleic acids trigger STING-dependent signaling during infection or stress.
Purpose of the Study:
- To review the emerging, inflammation-independent roles of STING.
- To highlight STING's function in regulating metabolic pathways.
- To discuss the interconnectedness of immunity and metabolism via STING.
Main Methods:
- Literature review and synthesis of recent findings on STING.
- Analysis of studies investigating STING's role in metabolic control.
- Discussion of the implications for homeostasis and pathology.
Main Results:
- STING plays a crucial role beyond immune signaling, influencing metabolic pathways.
- Evidence shows STING impacts multiple levels of metabolic regulation.
- The interplay between STING, immunity, and metabolism is increasingly recognized.
Conclusions:
- STING's functions extend to metabolic regulation, impacting cellular homeostasis.
- Understanding STING's dual roles in immunity and metabolism is vital for disease research.
- STING represents a critical link between nucleic acid sensing, immune responses, and metabolic health.
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