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Updated: Aug 29, 2025
A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies
Published on: March 31, 2022
Use of skin flaps for reconstructive surgery in guinea pigs (Cavia porcellus)
Anna Linda Nógrádi1, Dóra Csatári1, Iain Cope2
1Department of Exotic Animal and Wildlife Medicine, University of Veterinary Medicine, Budapest, Hungary.
Background:
The aim of the study was to investigate the use of single-pedicle advancement flaps in the fixed skin regions of the head, neck and paravertebral region in guinea pigs.
Methods:
Ultrasonography was performed on the guinea pigs to visualise the vascular anatomy of the looser regions of the thorax and abdomen and the more fixed paravertebral region and neck. Flap surgeries were then planned and undertaken on seven guinea pigs, with six having tumours on the lip, under the eye, the forehead, the neck or the paravertebral pelvic region, and one having a large paravertebral pelvic scar of unknown origin altering the animal's movement. The previously recommended 2:1 flap length:base width ratio was not enough in most cases, so larger flaps (3.5:1) were required.
Results:
All seven single-pedicle advancement flaps survived and healed with outstanding results.
Conclusion:
The authors recommend to use reconstructive surgery in guinea pigs when there is a need to close large or difficult wounds, even on areas of fixed skin. Adequate arterial supply and sufficient venous outflow can be provided with larger flap length:base width ratios than previously suggested and can lead to full recovery.
