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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Published on: June 1, 2012

Towards Micropump- and Microneedle-based Drug Delivery using Micro Transdermal Interface Platforms (MicroTIPs).

Fjodors Tjulkins, Ryan Sebastian, Theo Guillerm

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|September 10, 2022

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Micro Transdermal Interface Platforms (MicroTIPs) integrate microneedles with advanced electronics for autonomous drug delivery. This study demonstrates controlled transdermal delivery, enhancing patient adherence and healthcare.

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Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Area of Science:

Biomedical Engineering
Microneedle Technology
Drug Delivery Systems

Background:

Current transdermal drug delivery methods face challenges with patient adherence and efficacy.
Minimally invasive microneedle arrays offer potential for improved drug absorption.
Integration of miniaturized electronics and sensors is crucial for autonomous systems.

Purpose of the Study:

To experimentally validate controlled transdermal drug delivery using microneedle arrays.
To assess the feasibility of integrating micropumps and sensors with microneedles for drug delivery.
To demonstrate the potential of Micro Transdermal Interface Platforms (MicroTIPs) for autonomous drug administration.

Main Methods:

Utilized 500 μm tall silicon microneedles in conjunction with a commercial micropump.
Integrated pressure and flow sensors with bespoke control electronics for precise delivery.
Employed ex-vivo human skin samples and a custom application/retraction system for testing.

Main Results:

Achieved leak-free transdermal drug delivery of 0.7-1.1 mL within one hour.
Demonstrated successful integration and operation of microneedles, micropump, and sensors.
Confirmed the feasibility of controlled drug administration through microneedle arrays.

Conclusions:

This work experimentally confirms the feasibility of combining micropumps with microneedle arrays for transdermal drug delivery.
The developed system shows promise for autonomous physiological monitoring and drug delivery applications.
MicroTIPs have the potential to increase patient adherence and enable devolved healthcare models.