A novel method for Magnetic Resonance Spectroscopy lipid signal suppression using Semi-classical signal analysis and...

Magnetic resonance spectroscopy (MRS) is a non-invasive method that enables the analysis and quantification of brain metabolites, which provide useful information about the neuro-biological substrates of brain function. Lactate plays a pivotal role in the diagnosis of various brain diseases. However, accurate lactate quantification is generally difficult to achieve due to the presence of large lipid peaks resonating at a similar spectral position. To overcome this problem several techniques have been proposed. However, most of them suffer from lactate signal loss or poor lipid peak removal. In this paper, a novel method for lipid suppression for MRS signal is proposed. The method combines a semi-classical signal analysis method and a bidirectional long short term memory technique. The method is validated using simulated data that mimics real MRS data.