Related Experiment Video

Updated: Aug 29, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.0K

A proof-of-concept study for the simulation of blood flow in a post arterial segment for different blood rheology

Gianna E Karanasiou, Vasileios S Loukas, Panagiota I Tsompou

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |September 10, 2022
    PubMed

    Insights

    This study shows that using non-Newtonian blood models is crucial for accurately simulating blood flow dynamics in stented arteries. The Newtonian model underestimates endothelial shear stress, impacting predictive models for cardiovascular disease treatment.

    Area of Science:

    • Biomedical Engineering
    • Fluid Dynamics
    • Cardiovascular Science

    Background:

    • Cardiovascular disease (CVD), particularly atherosclerosis, involves arterial plaque growth and reduced blood flow.
    • Stent implantation is a key intervention for restoring blood flow in diseased arteries.

    Purpose of the Study:

    • To investigate blood flow performance in patient-specific stented coronary arteries.
    • To evaluate the impact of Newtonian versus non-Newtonian blood fluid models on endothelial shear stress distribution.

    Main Methods:

    • Utilized Navier-Stokes and continuity equations for blood flow simulation.
    • Employed computational finite element models.
    • Investigated three non-Newtonian fluid models: Carreau, Carreau-Yasuda, and Casson.

    Main Results:

    • The Newtonian fluid model underestimates endothelial shear stress calculations.
    • The three non-Newtonian fluid models (Carreau, Carreau-Yasuda, Casson) showed similar shear stress distribution patterns.
    • Significant differences in shear stress distribution were observed compared to the Newtonian model.

    Conclusions:

    • Accurate blood flow modeling in stented arteries requires consideration of blood's non-Newtonian properties.
    • Non-Newtonian models provide a more realistic simulation of endothelial shear stress compared to Newtonian models.
    • This finding is critical for developing predictive models in cardiovascular disease treatment.

    More Related Videos

    Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section11:00

    Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

    Published on: July 19, 2016

    11.7K
    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro10:25

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

    Published on: March 19, 2016

    9.5K

    Related Concept Videos

    Blood Flow01:29

    Blood Flow

    Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
    70.8K
    Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

    Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

    Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
    139
    Autoregulation of Blood Flow01:17

    Autoregulation of Blood Flow

    Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
    Chemical Signaling in Autoregulation
    Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
    2.7K
    Development of Blood Vessels01:07

    Development of Blood Vessels

    The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
    The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
    721
    Pre-Procedural Guidelines for Assessing Blood Pressure01:10

    Pre-Procedural Guidelines for Assessing Blood Pressure

    Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
    621