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    Age-related changes in corneal backscatter dynamics were analyzed using Corvis ST technology. A proposed normalization method improves age-group separation, highlighting the shape parameter

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    Area of Science:

    • Ophthalmology
    • Biomedical Engineering
    • Corneal Imaging

    Background:

    • Corneal visualization Scheimpflug technology (Corvis ST) analyzes corneal structure through backscatter properties.
    • Corneal densitometry, assessing corneal clarity, often uses backscatter parameters.
    • Weibull distribution parameters of corneal backscatter aid in keratoconus diagnosis.

    Purpose of the Study:

    • To investigate age-related changes in corneal backscatter dynamics during air-puff induced deformation.
    • To evaluate the effectiveness of a proposed normalization method for age-related backscatter data.
    • To determine which Weibull distribution parameter (scale or shape) better reflects age-related information.

    Main Methods:

    • Retrospective analysis of Corvis ST data from 151 young (19-30 years) and 82 older (50-87 years) subjects.
    • Corneal segmentation and region selection (temporal, central, nasal) for Weibull distribution fitting.
    • Time-series analysis of Weibull scale and shape parameters before and after normalization.

    Main Results:

    • Apparent differences in Weibull parameters were observed between age groups, primarily in the nasal cornea.
    • A proposed normalization method significantly improved the separation between young and older subjects.
    • The shape parameter of the Weibull distribution, unlike the scale parameter, contained age-related information even in raw data.

    Conclusions:

    • Corneal backscatter dynamics exhibit age-related variations detectable by Corvis ST.
    • Normalization of dynamic corneal backscatter parameters is crucial for accurate age-related assessments.
    • The shape parameter of the Weibull distribution is a promising indicator of age-related corneal changes.