Changes in EEG Measures of a Recipient of the mRNA COVID-19 Vaccine - A Case Study

The current study is aimed to evaluate the effect of COVID-19 vaccine on human EEG and the persistence of the effect. Within a one-year-long resting EEG study period, the healthy male subject was administered two Comirnaty doses three weeks apart to prevent COVID-19. Fourteen recordings were acquired from the subject in one year: twelve reference and two post-vaccination recordings after administrating the second dose of Comirnaty. The changes in absolute powers of EEG frequency bands, EEG spectral asymmetry index (SASI), and Higuchi's fractal dimension (HFD) were analyzed. The results indicated a statistically significant increase in absolute gamma power, SASI and HFD values on the fifth day after the vaccination, while the EEG had restored its normal character on the twelfth day after vaccination. These measures seem to have higher sensitivity for the detection of the effects of the vaccine Clinical Relevance- This is the first study evaluating COVID-19 vaccine effect on healthy human EEG. The study indicated that the vaccine disturbs EEG but the impact is not long-lasting.