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Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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Gastric pacing response evaluated with simultaneous electrical and optical mapping.

Nipuni D Nagahawatte, Hanyu Zhang, Niranchan Paskaranandavadivel

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |September 10, 2022
    PubMed
    Summary

    Optical mapping offers a superior method for studying gastric pacing, overcoming limitations of traditional electrical mapping. This technique provides artifact-free visualization of bioelectrical activity, advancing understanding of pacing therapies for motility disorders.

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    Area of Science:

    • Gastroenterology
    • Biomedical Engineering
    • Electrophysiology

    Background:

    • Gastric pacing is a promising therapy for abnormal gastric bioelectrical activity.
    • High-resolution electrical mapping is limited by surface contact and pacing artifacts.
    • Optical mapping using voltage-sensitive dyes is an alternative with potential advantages.

    Purpose of the Study:

    • To simultaneously evaluate high-resolution optical and electrical mapping of gastric bioelectrical slow wave response to pacing.
    • To compare the efficacy and signal quality of optical versus electrical mapping during gastric pacing.

    Main Methods:

    • In vivo porcine stomach models (n=3) were used.
    • Gastric electrical activity was entrained using high-energy pacing.
    • Simultaneous high-resolution optical mapping (voltage-sensitive dyes) and electrical mapping (surface electrodes) were performed.

    Main Results:

    • Optical and electrical recordings of slow waves were concordant in timing and propagation direction.
    • Mean velocities and periods were comparable between optical and electrical signals.
    • Optical mapping provided clear signals free from pacing artifacts, unlike electrical recordings.

    Conclusions:

    • Optical mapping is a valuable, artifact-free technique for evaluating gastric pacing.
    • This method enhances preclinical understanding of gastric pacing for functional motility disorders.
    • Findings support the clinical relevance of optical techniques for assessing gastric pacing efficacy.