Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

2.7K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
2.7K
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

139
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
139
Blood Flow01:29

Blood Flow

70.8K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
70.8K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

783
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
783
Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

621
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
621
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

3.3K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood-contacting magnetic levitation bearing design using computational fluid dynamics for haemocompatibility.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Same author

Dissipated energy and efficiency as objective functions for the design of the NeoVAD rotary blood pump.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Same author

Machine learning based on computational fluid dynamics enables geometric design optimisation of the NeoVAD blades.

Scientific reports·2023
Same author

Dynamic Evaluation of an Active Axial Magnetic Levitated Bearing System in a Hemocompatibility Assessment Platform.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2022
Same author

Numerical and Experimental Analysis for a Magnetic Levitation System in a Hemocompatibility Assessment Platform.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2022
Same author

Use of magnetic resonance imaging to assess myocardial perfusion after transmyocardial laser revascularization.

The heart surgery forum·2009
Same journal

Analysis of End-Tidal CO2 Variability During Plateau Waves Episodes: An Information Theoretic Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

AI and Tomosynthesis for Breast Cancer Molecular Subtyping: A step toward precision medicine<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Towards Sustainable Protein Recovery from Biological Waste: Assessing Polyethersulfone-based Microfiltration.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of the cardiovascular response to standardized polymicrobial peritonitis experimental model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Automated Wrist Ultrasound Image Bone Enhancement and Segmentation Using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
See all related articles

Related Experiment Video

Updated: Aug 29, 2025

In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow
07:00

In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow

Published on: March 14, 2021

3.3K

Physiological Control Algorithm for a Pulsatile-flow 3D Printed Circulatory Model to Simulate Human Cardiovascular

Preston Peak, Victor Tedesco, Simon Kiang

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |September 10, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Researchers created a controllable mock circulatory loop (MCL) using 3D printing to accurately simulate the human cardiovascular system. This advanced test platform aids in developing medical devices and surgical training.

    More Related Videos

    In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
    07:30

    In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

    Published on: November 3, 2015

    9.7K
    Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow
    09:34

    Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow

    Published on: October 31, 2019

    6.6K

    Related Experiment Videos

    Last Updated: Aug 29, 2025

    In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow
    07:00

    In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow

    Published on: March 14, 2021

    3.3K
    In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
    07:30

    In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

    Published on: November 3, 2015

    9.7K
    Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow
    09:34

    Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow

    Published on: October 31, 2019

    6.6K

    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Physiology
    • Medical Device Testing

    Background:

    • Mock circulatory loops (MCLs) model the human cardiovascular system for testing medical devices.
    • Accurate simulation requires replicating physiological responses like the Frank-Starling Mechanism.
    • Existing MCLs may lack controllable environments for precise physiological simulation.

    Purpose of the Study:

    • To develop a controllable mock circulatory loop (MCL) capable of simulating the human cardiovascular system.
    • To validate the MCL's ability to reproduce pulsatile physiological flow and hemodynamic environments.
    • To establish an in vitro platform for medical device testing and surgical training.

    Main Methods:

    • Utilized a 3D printed silicone vascular structure to represent human anatomy.
    • Implemented an elastance function template to control the simulated left ventricle.
    • Generated controllable pulsatile physiological flow within the MCL.

    Main Results:

    • Successfully created a controllable pulsatile flow within the 3D printed vascular structure.
    • The MCL accurately simulated the hemodynamic environment of the human cardiovascular system.
    • Demonstrated the ability to reproduce human physiological responses in a controlled setting.

    Conclusions:

    • The developed MCL provides an accurate in vitro test platform for the human cardiovascular system.
    • This technology serves as a valuable tool for testing mechanical circulatory support (MCS) devices.
    • The platform offers an ideal training environment for surgeons to practice procedures and understand physiological conditions.