True location of deep brain stimulation electrodes differs from what is seen on postoperative magnetic resonance...

Deep brain stimulation (DBS) is an established yet growing treatment for a range of neurological and psychiatric disorders. Over the last decade, numerous studies have underscored the effect of electrode placement on the clinical outcome of DBS. As a result, imaging is now extensively used for DBS electrode localization, even though the accuracy of different modalities in determining the true coordinates of DBS electrodes is less explored. Postoperative magnetic resonance imaging (MRI) is a gold standard method for DBS electrode localization, however, the geometrical distortion induced by the lead's artifact could limit the accuracy. In this work, we investigated to what degree the difference between the true location of the lead's tip and the location of the tip estimated from the MRI artifact varies depending on the MRI sequence parameters, acquisition plane, phase encoding direction, and the implant"s extracranial trajectory. Clinical Relevance- Results will help researchers and clinicians to estimate the true location of DBS leads and contacts from postoperative MRI scans.